於其他甲型阻斷劑使用無效之前列腺肥大病人改善其下泌尿道症狀
鄭嘉緯、歐建慧
國立成功大學醫學院附設醫院泌尿部
Chia-Wei Cheng, Chien-Hui Ou
Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University
Lower urinary tract symptom improvement in enlarged prostate patient failing to other a-blockers after Silodosin treatment
Silodosin
Purpose: To evaluate subjective symptom improvement of silodosin treatment for BPH patients with unsatisfactory response to initial α1 blocker.
Methods: 50 BPH patients with unsatisfactory response to initial α1 blocker were included in this study. IPSS were recorded before and after administration of 4 weeks of silodosin. No drug withdrawal period was provided when switching the drug. We evaluate subjective improvement of silodosin treatment according to the International Prostate Symptom Score.
Results: 28 patients (56 % ) had subjectively improved the International Prostate Symptom Score total score but 22 patients failed to have symptom improvement. Comparison of changes revealed that silodosin showed significant improvement of nocturia. The most frequent adverse drug reaction was ejaculatory disorder with silodosin.
Conclusions: In BPH/LUTS patients, silodosin exhibits some efficacy in improving subjective symptoms especially in nocturia for BPH patients with unsatisfactory response to initial α1 blocker.