台灣族群鋅運輸基因與良性攝護腺肥大的相關性
張浚峰、王強庭、梅健泰、倪英睿、卓龍翔、李蕎青
國軍高雄總醫院 外科部 泌尿外科
Regulation of Zinc transport gene with prostatic hyperplasia in Taiwan
Chun-Feng Chang, Chiang-Ting Wang, Chien-Tai Mei, Ying-Jui Ni,
Lung-Hsiang Cho, Chiao-Ching Li
Divisions of Urology, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
Purpose: We investigate the relationship of Zinc transporter gene ZIP (SLC39A1) and ZnT (SLC30A2)
polymorphism in Taiwanese patients with BPH.
Materials and Methods: A total 45 BPH and 24 CVD patients and 48 healthy control subjects were enrolled. We analyzed the single nucleotide polymorphisms of SLC39A1 and SLC30A2 gene using the polymerase chain reaction (PCR)-based restriction analysis.
Results: There was significant differences for SLC30A2 gene polymorphism (rs11247851) by Chi-Square test between in control and BPH group (p<0.05, Chi-Square value was 6.338) and control and CVD group (p<0.05, Chi-Square value was 6.887). The result displays that T residues have a protection for BPH and CVD diseases, SLC30A2 gene polymorphism (rs11247851) was significant for regulate transport Zinc in BPH and CVD, but the protective effect was better in BPH than CVD disease.
Conclusions: SLC30A2 gene polymorphism (rs11247851) was significant for regulating transport Zinc in BPH and CVD and T residues has a protection in BPH and CVD diseases but the protective effect was better in BPH than CVD disease. The cause maybe was relational concentrations of Zinc, prostate contain more Zn than cardiovascular tissue, and the transport zinc effect was larger by
SLC30A2 gene polymorphism (rs11247851) in BPH than CVD.