甲殼素在間質性膀胱炎治療之角色探討
何東儒12、陳志碩、林威宇、黃雲慶、林健煇
長庚醫院嘉義分院 外科部 泌尿科；1長庚大學臨床 醫學研究所 2長庚科技大學 護理系，
The Role of Chitosan in Treatment Interstitial Cystitis
Dong-Ru Ho12, Chih-Shou Chen, Wei-Yu Lin, Yun-Chin Huang, Jian-Hui Lin
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Taiwan
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taiwan
Department of Nursing, Chang Gung University of Science and Technology, Taiwan
Purpose: Since glycosaminoglycans plays an important role in the pathophysiology and treatment of interstitial cystitis, we hope to investigate the potential benefit of small molecular chitosan, which is the monomer of glycosaminoglycans, in the treatment of cyclophosphamide induced interstitial cystitis rat model.
Materials and Methods: We used cyclophosphamide (CYP) intraperitoneal injection to induced chronic cystitis in female rats. Treatment with intravesical chitosan instillation was performed along with cystitis induction. Cystometrogram was performed to evaluate intravesical pressure and intercontraction interval.
Results: There was significant difference in intravesical pressure and intercontraction interval when rats treated with chitosan. Systemic cytokines including IL-6 and TNF-a increased in CYP rats while IL-10 and IFN-r decreased. The trend is mildly reversed in IL-10 when intravesical chitosan was applied.
Conclusions: Chitosan may potentiate the effect of cyclophosphamide. Spleen cytokines changes indicated that locally applied chitosan may affect systemic response in rats. Intravesical chitosan had a role further more than a coating agent in bladder.