單純疱疹病毒與罹患攝護腺癌的世代研究

曹曜軒¹、張君愷²、耿俊閎¹、阮雍順³

高雄市立小港醫院 泌尿科¹；高雄醫學大學附設中和紀念醫院 泌尿科²；高雄市立大同醫院 泌尿科³

Herpes Simplex Virus and Subsequent Risk of Prostate Cancer: A Cohort Study in Taiwan

Yao-Hsuan Tsao¹, Chun-Kai Chang², Jiun-Hung Geng¹, Yung-Shun Juan³

Divisions of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan ¹

Divisions of Urology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan²

Divisions of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan³

Purpose: We investigated whether herpes simplex virus (HSV) is associated with an increased risk of developing prostate cancer (PCa), in a cohort study in Taiwan.

Materials and Methods: We identified 30752 men (age>=20 y/o ) diagnosed with prostate cancer (23064 without HSV infected, and 7688 with HSV infected) between 2000 and 2007, from the Taiwan Longitudinal Health Insurance Database 2000. Cox's proportional hazard regression analysis was performed to estimate the effect of HSV on the PCa risk.

Results: The risk of developing PCa was significantly higher in the HSV infected cohort (adjusted HR =1.53, 95% CI = 1.29-1.81) than in the group without HSV infected. Further analyses indicated that patients with STDs of other pathogens had no significantly greater risk of developing PCa.

Conclusions: We found that sexually transmitted diseases may play an etiological role in the development of PCa in Taiwanese men, particularly in those with HSV infected. Further studies are warranted on the association between HSV and PCa in other countries. particularly where the prevalence of PCa is high.