獨立於血清中睪固酮濃度，台灣中老年男性之性荷爾蒙結合球蛋白與脂肪激素及代謝症候群危險性相關
劉家駒1-3 李永進1-2 黃書彬1,2 鄭凱鴻4 謝翠娟5 林曉華6
王起杰1,2 黃俊農1,2 蔡嘉駿7 吳文正1,2,7
高雄醫學大學附設醫院 泌尿部1
高雄醫學大學 醫學院 醫學系 泌尿學科2
衛生福利部 屏東醫院 泌尿科3
高雄醫學大學附設醫院 心臟內科4
高雄醫學大學 醫學院 醫學研究所5
衛生福利部 屏東醫院 檢驗科6
高雄市立大同醫院(委託財團法人高雄醫學大學經營) 泌尿科7
Independent of testosterone level, SHBG is associated with adipocytokine levels as well as the risk of metabolic syndrome in middle- to old-aged Taiwanese men
Chia-Chu Liu1-3, Yung-Chin Lee1,2, Shu-Pin Huang1,2, Kai-Hung Cheng4, Tusty-Jiuan Hsieh5, Hsiao-Hua Lin6, Chii-Jye Wang1,2, Chun-Nung Huang1,2, Chia-Chun Tsai7, and Wen-Jeng Wu1,2,7
1Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung
2Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung
3Department of Urology, Pingtung Hospital, Ministry of Health and Welfare, Pingtung
4Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung
5Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung
6Department of Laboratory Medicine, Pingtung Hospital, Ministry of Health and Welfare, Pingtung
7Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung
Abstract
Purpose: In addition to testosterone (T), emerge role of sex hormone-binding globulin (SHBG) in the pathogenesis of metabolic syndrome (MetS) have been noted recently. However, reports of their associations with serum adipocytokine levels were still limited. Therefore, we performed this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin.
Materials and Methods: The cross-sectional data of Taiwanese men older than 40 years were collected from a free health screening held between August 2010 and February 2012 in Kaohsiung city, Taiwan. All participants completed a health questionnaires, received a detailed physical examination and provided 20 cc fasting blood samples drawn between 8:00 and 11:00 AM for biochemical and hormone evaluation.
Results: A total of 614 men with the mean age of 55.8±5.7 years were analyzed. Subjects with lowest quartile of TT and SHBG levels pose 1.58- and 3.22- risks to have MetS individually, when compared to those with highest quartile of TT and SHBG levels after adjusting for age and lifestyle factors. However, only SHBG remains its significance after simultaneous adjustment of both TT and SHBG levels. In addition, SHBG was significantly correlated with both adiponectin and leptin levels even after adjusting for age, lifestyle factors, BMI and TT levels.
Conclusion: In a large sample of aging Taiwanese men, SHBG served as a major predictor for the risk of MetS and correlated with serum adiponectin and leptin levels that are independent of T. Further studies are still needed to elucidate the real role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.