攝護腺肥大增加罹患大腸癌之風險: 全人口資料庫研究
賴宗豪1、石宏仁1、李良明1、溫玉清1、林克勳1、林雍偉1、蕭志豪1、黃俊仁2
1台北市立萬芳醫院 泌尿科；2台北市立萬芳醫院 麻醉科
Benign prostatic hyperplasia increases the risk of colon cancer: A population-based study
Chung-Howe Lai1, Hung-Jen Shih1, Liang-Ming Lee1, Yu-Ching Wen1, Ke-Hsun Lin1, Yung-Wei Lin1, Chi-Hao Hsiao1, Chun-Jen Huang2
1 Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
2 Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Purpose:
To evaluate the relationship between benign prostatic hyperplasia(BPH) and the risk of colon cancer using a nationwide population-based data set.
Materials and Methods:
Data was retrieved from Taiwan National Health Insurance Database between January, 2000 and December, 2012. We analyze the risk of colon cancer in the BPH cohort, both age and gender-matched (1:1) with the control cohort. The primary end point was the diagnosis of colon cancer. The risks of colon cancer for all subjects and usage of alpha blockers on these newly diagnosed BPH patients were estimated by using the multivariable Cox proportional hazards regression model.
Results:
A total of 50,846 subjects (aged 40-99 years), including 25,423 in each cohort, were identified. The BPH cohort had a significantly higher incidence of colon cancer (1.5% vs 0.9%, P < 0.001) compared to the non-BPH cohort. Our data demonstrated that the BPH cohort in all subjects had a significantly higher risk of colon cancer compared to the non-BPH cohort (hazard ratio = 1.64, 95% confidence intervals = 1.38 – 1.94, p < 0.001) after propensity score adjustment. Besides, we also found that usage of alpha blockers >6 months in these newly diagnosed BPH patients demonstrated a significantly decreased risk of colon cancer (hazard ratio = 0.38, 95% confidence intervals = 0.26 – 0.54, p < 0.001)
Conclusion:
The subjects with BPH exhibited a 64-77% increased risk of colon cancer. Furthermore, the usage of alpha blockers over 6 months in these patients showed a decreased risk of colon cancer.