CSN6表現與台灣上泌尿道上皮癌之相關性
李怡琛1,2, 李威明2,3,4,8, 連培因10, 徐偉齊2,3,4 , 林慧惠2,3, 張玲麗2,7, 李健逢8,9, 吳文正2,3,4,5,
李經家2,3,4,5, 葉信志 2,3,4,5 ,柯宏龍 2,3,4
高雄醫學大學 解剖學科1 醫學研究所2 泌尿學科3 微生物學科4
高雄醫學大學附設醫院泌尿科5、病理科6、大同醫院泌尿科7、署立屏東醫院泌尿科8 、奇美醫院病理科9
Prognostic value of CSN6 overexpression in upper tract urothelial carcinomas in Taiwan
Yi-Chen Lee1,2, Wei-Ming Li2,3,5,7, Peir-In Liang6, Wei-Chi Hsu2,3 , Hui-Hui Lin2,5, Lin-Li Chang2,4, Chien-Feng Li9, Wen-Jeng Wu2,3,5,7, Ching-Chia Li2,3,5, Hsin-Chih Yeh 2,3,5,7 , Hung-Lung Ke 2,3,5
1Department of Anatomy, 2Graduate Institute of Medicine College of Medicine, 3Department of Urology, 4Department of Microbiology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung.5Department of Urology, 6Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.7Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung.8Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung. 9Department of Pathology, Chi-Mei Medical Center, Tainan.
Abstract
Objectives: CSN6 has diverse functions in cellular and developmental processes, including cell cycle control, signal transduction, transcriptional activation and tumorigenesis. Besides, CSN6 also be implicated that is highly expressed in several human cancers, for example, colorectal cancer, breast cancer. However, there are rarely paper about CSN6 expression in upper tract urothelial carcinoma (UTUC). Our aim of this study is to evaluate the clinical significance of CSN6 in upper tract urothelial carcinoma (UTUC).
Material and method: Eighty-nine cases of UTUC were included in this study and CSN6 expression was evaluated by immunohistochemistry and the association of CSN6 expression with clinicopathological variables was analyzed.
Results: CSN6 expression was significantly correlated with patients who had high stage (p=0.006), gender (p=0.025) and serum creatinine levels (p=0.014). In Univariate and multivariable analysis of overall survival for UTUC, we found that high CSN6 expression was associated with poor overall survival (p=0.015).
Conclusions: Our findings indicate that CSN6 expression is a potential biomarker for predicting patient survival. Further study is necessary to investigate the role of CSN6 in the progression of upper tract urothelial carcinoma.