陰莖背神經與海綿體神經間的細小神經交通支在勃起功能障礙中的角色
陳燕麟1,2,3、吳宜娜3,4、林盈宏3、江漢聲3,5
天主教耕莘醫院病理部；1 輔仁大學化學系,2輔仁大學基礎醫學研究所,3輔仁大學食品營養博士學程；4台北醫學大學附設醫院泌尿科5
The nerve branches between the dorsal penile nerves and the cavernous nerves should be the determinant of erectile function
Yen-Lin Chen1,2,3, Yi-No Wu3,4, Ying-Hung Lin3, Han-Sun Chiang3,5
Department of Pathology, Cardinal Tien Hospital1, Department of Chemistry, Fu-Jen Catholic University2, Graduate Institute of Basic Medicine, Fu-Jen Catholic University3, Ph. D Program in Nutrition & Food science, Fu Jen Catholic University4, Department of Urology, Taipei Medical University Hospital5, Taipei, Taiwan
Purpose:
Literatures showed the changes of neuronal nitric oxide synthases (nNOS) in the dorsal penile nerves (DPNs) are consistent with the cavernous nerves (CNs) injury in rat model. However, the anatomical relationship and morphological changes between the DPNs and the CNs after injury have never been clearly explored in rats.
Materials and Methods:
There are 5 groups including a sham group, and four groups of 7th day, 14th day, 21th day and 28th day after BCNI. Anatomical relationships between the DPNs and the CNs were dissected. The erectile function, immunohistochemistry and transmission electron microscope were also done.
Results:
The DPNs connect the CNs through communicating nerve branches in rats. In the 14th day, the number of the DPNs small branches is lowest and the worst damage of myelin sheath in BCNI group. The number of the nNOS positive nerves, including main and small branches of DPNs, is positively correlated with the ICP.
Conclusion:
We demonstrated communicating nerve branches between the DPNs and the CNs in rats. The loss of small branches and reduced number of nNOS positive nerves could be a representative feature of the DPNs after BCNI. The communicating nerve branches could be the determinant of erectile function in rats.