CSF-1表現與台灣上泌尿道上皮癌之相關性
Prognostic value of CSF1 overexpression in upper tract urothelial carcinomas in Taiwan
徐偉齊1,7, 李怡琛2, 連培因7, 張玲麗4, 黃阿梅1,5,6, 吳文正1,3,7,9, 李經家7, 9,
李威明3,7,10, 林慧惠7, 柯宏龍3,7*
高雄醫學大學 醫學研究所1 、解剖學科2、 泌尿學科3 、微生物學科4、生化學科5、臨床醫學研究所6 ; 高雄醫學大學附設醫院 泌尿科7、病理科8; 大同醫院泌尿科9; 衛生福利部屏東醫院泌尿科10
Wei-Chi Hsu 1,7, Yi-Chen Lee 2, Peir-In Liang 7, Lin-Li Chang 4, A-Mei Huang 1,5,6,
Wen-Jeng Wu 1,3,7,9, Ching-Chia Li 7, 9, Wei-Ming Li 3,7,10, Hui-Hui Lin 7, Hung-Lung Ke 3,7*
1 Graduate Institute of Medicine, College of Medicine, 2 Department of Anatomy, 3 Department of Urology, 4 Department of Microbiology, 5 Department of Biochemistry, 6 Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung ; 7 Department of Urology, 8 Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.
9 Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung.10 Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung.
Purpose: Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein. The main role of CSF-1 is as a hematopoietic growth factor that modulate proliferation, survival and differentiation of macrophage. Moreover, CSF-1 has also been reported to be aberrantly expressed in several human cancers. However, the precise role of CSF-1 in upper tract urothelial carcinoma (UTUC) has not been studied. In this study, we evaluated the clinical significance of CSF-1 expression in UTUC.
Materials and methods: One hundred and sixteen cases of UTUC were included in this study. All of them provided cancer tissue samples and 50 of them provided normal urothelium samples. CSF-1 expression was evaluated by immunohistochemistry and the associations of CSF-1 expression and clinicopathological variables were analyzed.
Results: CSF-1 expression was higher in UTUC than normal urothelium (p <0.01). CSF-1 expression was significantly correlated with tumor size (p=0.04), tumor stage (p <0.001), distant metastasis (p =0.009) and cancer recurrence (p =0.006). High CSF-1 expression was associated with poor disease-free survival (p =0.014) and cancer-specific survival (p <0.001). In multivariable analysis, we also found that high CSF-1 expression was an independent predictor of poor disease-free survival (hazard ratio =1.97; p =0.03) and cancer-specific survival (hazard ratio =4.12; p=0.015).
Conclusions: Our findings indicate that CSF-1 expression is a potential prognostic marker for predicting patient survival and recurrence in UTUC.