心血管風險因子是否能預測勃起功能障礙患者中的性腺功能低下？

鄭柏禹、吳翊豪

基隆長庚紀念醫院 外科部 泌尿外科

Is the risk factor for cardiovascular event able to predict hypogonadism among patients with erectile dysfunction?

Bo-Yu Cheng, Yi-Hao Wu

Department of Urology, Keelung Chang Gung Memorial Hospital

Purpose: To explore the risk factors associated with hypogonadism among patients with erectile dysfunction in Taiwanese.

Materials and Method: A total of 196 patients with erectile dysfunction (ED) were enrolled between February 2020 and June 2025 in Keelung Chang Gung Memorial Hospital (CGMH), including 63 patients with hypogonadism. Hypogonadism was defined as a total testosterone level <350 ng/dL according to the criteria of the European Association of Urology. Atherogenic indices, including CRI-1, CRI-2, AIP, and AC, were derived from lipid profile data, whereas the triglyceride–glucose index was calculated using triglyceride and fasting glucose levels. Univariate analyses were performed using the Student’s t-test and the chi-square test. Logistic regression analysis was subsequently conducted to establish the final model.

Results: No significant differences in demographic factors, including age, alcohol consumption, and smoking status, were observed between ED patients with hypogonadism (n = 63) and those without hypogonadism (n = 133). BMI, plasma levels of triglycerides, HDL, and VLDL, as well as atherogenic indices including CRI-1, AIP, AC, and the triglyceride–glucose index, showed significant associations with hypogonadism among patients with ED. In the multivariable logistic regression analysis, only the Atherogenic Index of Plasma (AIP) remained significant in the final model (OR 11.44, 95% CI 3.30–39.67, p = 0.0001).

Conclusions: Poor lipid profiles are strongly associated with hypogonadism among patients with erectile dysfunction, suggesting the importance of concurrent management of dyslipidemia in this population.