第二型糖尿病於中年男性與龜頭炎之風險

吳昀叡^1,2、賴宜弘³、王炯珵^1,4

¹恩主公醫院外科部泌尿科；²台灣大學附設醫院泌尿部；

³亞東科技大學醫務管理系; ⁴中原大學生物醫學工程系

Type 2 Diabetes Mellitus, but not Hypertension or Hyperlipidemia, Increases the Risk of balanitis and in Middle Age Men

Yun-Rui Wu^1,2, Yi-Horng Lai³, Chung-Cheng Wang^1,4

¹Department of Urology, En Chu Kong Hospital, New Taipei City, 23702, Taiwan.

²Department of Urology, College of Medicine, National Taiwan University, Taipei City, 100, Taiwan.

³Department of Healthcare Administration, Asia Eastern University of Science and Technology, New Taipei City, 22061, Taiwan

⁴Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, 32023, Taiwan.

Purpose:

Introduction: Diabetes mellitus (DM) can be an important cofactor in the development of balanitis. Here, we explored the association between balanitis and DM, hypertension, and hyperlipidemia in the Taiwanese population, using a population-based data set.

Materials and Methods:

The research data in this study were obtained from Taiwan’s National Health Insurance Research Database between January 1997 and December 2010. We identified 12,819 patients who had a diagnosis of DM, and randomly matched 38,457 subjects as controls in men between 30 and 49 years of age. The data were analyzed with Poisson regression analysis and with Cox regression with a frailty model after propensity score matching.

Results:

DM (odd ratio (OR) = 1.43, p < 0.01), and age (OR = 0.71, p < 0.01), but not hyperlipidemia (OR = 0.96, p =0.36), or hypertension (OR = 1.09, p = 0.10) had an impact on the development of balanitis. DM was a risk factor associated with balanitis (HR = 1.42, 95% CI = 1.27~1.68, p < 0.01), whereas no statistical difference was noted between penile inflammation and hypertension (HR = 0.98, 95% CI = 0.89~1.09) and hyperlipidemia (HR = 1.03, 95% CI = 0.92~1.14).

Conclusion:

DM and younger age, but not hypertension or hyperlipidemia, were associated with an increased risk of balanitis in middle age men. Our findings suggest the need for preemptive circumcision for selective men with DM may to prevent diabetes-associated penile inflammatory disorders.