多次復發之後腹腔脂肪肉瘤：病例報告
林祖丞1、許威群1,2、羅濟青1、馮思中1,3,*
1. 林口長庚紀念醫院外科部泌尿科；2.長庚大學醫學院中醫學系；3. 長庚大學醫學院
A Retroperitoneal Liposarcoma with Multiple Local Recurrences: A Case Sharing
Tsu-Chen Lin1, Wei-Chun Hsu1,2, Chi-Chin Lo1, See-Tong Pang1,3,*
1. Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan；2. School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan；3. College of Medicine, Chang Gung University, Taoyuan City, Taiwan
*Correspondence
Abstract
Sarcoma, a primitive multipotential mesenchymal precursors-derived malignant tumor, is a relatively rare malignancy of less than 1% of all malignancies. Liposarcoma represents a histological subtype of soft tissue sarcoma, which is derived from adipocytic cell lineage. Retroperitoneal sarcomas are associated with poor disease-specific survival and local recurrence-free survival. Its 10-year disease-specific survival is around 35%, and 10-year local recurrence-free survival is around 40%. Surgical resection of the retroperitoneal liposarcoma is currently the only possible curative-intent treatment. We herein present a case of retroperitoneal liposarcoma who received a compartmental surgical resection 8 years ago, with multiple local recurrences and received surgical resection each time. Different treatments, including surgical resection, radiotherapy and other systemic therapy, such as chemotherapy, targeted therapy and immunotherapy, have been explored in this group of patients. However, surgical resection remains the main therapeutic approach for localized retroperitoneal sarcoma. Meanwhile, in patients with local recurrence, the role of surgery is a more complicated issue, and multiple factors, including patient’s performance status, co-morbidities, histologic subtype, disease biology and the nature of previous operations, need to be taken into considerations. Though surgical operation of patients with recurrent retroperitoneal liposarcoma is individualized, surgical resection when feasible might add to the survival benefit in this population.