病例報告:陰囊之乳房外柏哲德氏病

劉佳旻、蔡育賢

國立成功大學醫學院附設醫院泌尿部

Case report: Extramammary Paget’s disease of the scrotum

Chia-Min Liu, Yuh-Shyan Tsai
National Cheng Kung University Hospital

 

A 79-year-old male presented to the urology clinic with progressive tenderness of right scrotal skin for six months. Physical examination showed erythematous crusted plaques with white scaly margin over right hemi-scrotum. Topical steroid and antibiotics were initially prescribed but in vain. Skin biopsy was performed and pathology revealed large, pale, vacuolated atypical cells in the epidermis, suggesting Paget’s disease. Abdominal CT showed no evidence of underlying malignancy nor lymph node metastasis. Right scrotal wall excision was performed with safe margin confirmed by intraoperative frozen section. Final pathology report confirmed extramammary Paget’s disease. The patient was under follow-up for five years by now without recurrence.

As an uncommon intraepithelial adenocarcinoma, extramammary Paget’s disease is often misdiagnosed as an inflammatory or infectives skin condition and a median delay of 2 years in diagnosis was reported. The most common presenting symptom in extramammary Paget disease is pruritus, but burning, tenderness, and edema are reported as well. Hard nodules and regional lymph node enlargement may develop as a consequence of the presence of an underlying carcinoma. Owing to its association with another malignancy and potentially invasive behavior, early biopsy is the key for early diagnosis and treatment. Surgical excision remains the mainstay of therapy.
 
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    發表人
    TUA會計採購組
    單位
    台灣泌尿科醫學會
    標籤
    非討論式海報
    建立
    2023-01-03 22:42:53
    最近修訂
    2023-01-03 22:43:43
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