組蛋白-賴氨酸N-甲基轉移酶基因型與台灣膀胱癌風險增加的關聯性
廖丞晞1,2,3,4 張文馨2,3 胡佩欣6 吳錫金5 蔡佳紋2,3 包大靝2,3,4
1國軍台中總醫院泌尿外科; 2中國醫藥大學臨床醫學研究所; 3Terry Fox癌症研究室;
4國防醫學院臨床醫學研究所; 5中國醫藥大學附設醫院泌尿外科; 6彰化基督教醫院眼科部
The association of enhancer of zeste 2 (ezh2) genotypes to taiwanese bladder cancer risk
Cheng-Hsi Liao1,2,3,4 , Wen-Shin Chang2,3 ,Pei-Shin Hu3,6, Hsi-Chin Wu5, Chia-Wen Tsai2,3,and Da-Tian Bau1,2
1 Department of Urology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
2 Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
3 Terry Fox Cancer Research Laboratory;
4 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.;
5 Department of Urology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
6 Department of Ophthalmology, Changhua Christian hospital, Changhua, Taiwan, R.O.C.
Purpose: Bladder cancer is the sixth most common cancer worldwide and its incidence is particularly high in many developed regions including southwestern Taiwan. However, the genetic contribution to the etiology of bladder cancer is not well-understood. The aim of this study was to evaluate the association of the enhancer of zeste homolog 2 (EZH2) genotypes with Taiwan bladder cancer risk.
Materials and Methods: Three polymorphic variants of EZH2 were analyzed regarding their association with bladder cancer risk, and three hundred and seventy-five patients with bladder cancer and same number of age- and gender-matched healthy controls recruited were genotyped by the PCR-RFLP method.
Results: Among the three polymorphic sites examined, the genotypes of EZH2 rs887569 (C to T), but not rs41277434 (A to C) or rs3757441 (T to C), were positively associated with bladder cancer risk (p for trend =0.0146). Individuals with the EZH2 rs887569 TT genotypes were associated with decreased cancer risk than those with wild-type CC genotype. The stratified analyses showed that EZH2 rs887569 TT genotypes had protective effects on non-smokers but obviously not on smokers.
Conclusions: Our findings provide evidence that the T allele of EZH2 rs887569 may be associated with the lower risk of bladder cancer development, especially among non-smokers.