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血糖控制增進在非肌肉侵襲性膀胱癌病人中膀胱藥物灌注的療效
王又德1、張兆祥1、黃志平1、楊啟瑞1、吳錫金2、陳冠亨1
1中國醫藥大學附設醫院 泌尿部；2中國醫藥大學北港分院 泌尿部
Glycemic control improved the effect of instillation therapy in patient of non-muscle invasive bladder cancer
Yu De Wang1, Chao-Hsiang Chang1, Chi-Ping Huang1, Che-Rei Yang1, Hsi-Chin Wu2, Guang-Heng Chen1
1Department of Urology, China Medical University Hospital, Taichung, Taiwan
2Department of Urology, China Medical University Beigang Hospital, Yunlin, Taiwan
 
Purpose: To evaluate the association between DM and glycemic control with prognosis of non-muscle invasive bladder cancer (NMIBC).
Materials and methods: We retrospectively analyzed 64 patients diagnosed clinical stage T1, high grade bladder cancer who received instillation therapy between 2007 and 2015. Demographic information including age, gender, ASA, diabetes (DM) or not, tumor characteristic, type of instillation therapy, and HbA1c level were recorded. Univariate Cox regression analysis was used to analyze the factors influencing survival. Kaplan-meier analysis was used to evaluate recurrence free survival, progression free survival and overall survival.
Results: 19 of 64 patients were diagnosed DM. The mean age was 67.1 year old, male accounts for 79.7% of all patients, and the mean follow up months was 39.9, There is no significant difference between DM, and non-DM group in demographic information except for proteinuria(p<0.0001). Cox univariate analysis showed DM significantly affects recurrence free survival and overall survival while CIS differentiation reaches significance in progression free survival. In 3-year recurrence free survival rate, DM poor control group (HbA1c>7) significantly inferior to non-DM group (55%,vs 87% p=0.01), while no difference between DM good control group(HbA1c<7) and non-DM group(p=.42). Compared to non-DM group, DM poor control group had significantly inferior survival rate (Log Rank test, p=0.008), while DM good control group did not reach significance difference (Log Rank test, p=0.41)
Conclusion: Glycemic control by reducing HbA1c level below 7 improved the recurrence free and overall survival in patient of NMIBC who underwent instillation therapy.
 
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    1. 知識庫
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    5. 2017半年會
    6. 摘要
    資料夾名稱
    摘要
    發表人
    TUA秘書處
    單位
    台灣泌尿科醫學會
    標籤
    討論式海報
    建立
    2016-12-20 23:37:13
    最近修訂
    2017-02-14 22:23:40
    1. 1.
      Podium
      1. 1.1
        (PD1-1) The long-term survival outcome of radical prostatectomy for localized prostate cancer with positive lymph node
      2. 1.2
        (PD1-2) Oncologic outcomes at 8 years following robotic assisted radical prostatectomy
      3. 1.3
        (PD1-3) Predictors of PSA biochemical recurrence in patients undergoing primary whole gland prostate ablation with high intensity focused ultrasound in 178 patients
      4. 1.4
        (PD1-4) High endothelin-1 expression predicts good prognosis in upper tract urothelial carcinoma
      5. 1.5
        (PD1-5) Prior tuberculosis infection does not affect the efficacy or major adverse effects of intravesical Bacillus Calmette-Guerin treatment for urothelial carcinoma of the urinary bladder – A nationwide population-based study
      6. 1.6
        (PD1-6) The prediction of T3a disease on pre-operative 3T mp-MRI: a correlation study with the pathology of robotic assisted radical prostatectomy
      7. 1.7
        (PD2-1) Female bladder neck dysfunction-a videourodynamic analysis of female voiding dysfunction
      8. 1.8
        (PD2-2) The association of enhancer of zeste 2 (ezh2) genotypes to taiwanese bladder cancer risk
      9. 1.9
        (PD2-3) The molecular mechanism of autophagy via mitochondrial and endoplasmic reticulum pathway in ketamine-induced ulcerative cystitis in animal model
      10. 1.10
        (PD2-4) Risk factors of wound complication after radical cystectomy with urinary divertion
      11. 1.11
        (PD2-5) The outcomes of scrotal exploration with epididymo-vasostomy in patients with non-iatrogenic, non-traumatic obstructive azoospermia
      12. 1.12
        (PD2-6) The risk factors influencing patency rate for vasectomy reversal
    2. 2.
      Moderate Poster
      1. 2.1
        (MP1-1) The incidence and management of lymphoceles after robotic-assisted laparoscopic radical prostatectomy
      2. 2.2
        (MP1-2) Sequential treatment of metastatic renal cell carcinoma with targeted therapy---experience of taichung veterans general hospital
      3. 2.3
        (MP1-3) Inhibition of cisplatin-induced autophagy by overexpression of miR-30a-5p
      4. 2.4
        (MP1-4) Factors affect quality of life in patients with renal and upper urinary tract carcinoma after surgery in Taiwan: a preliminary report
      5. 2.5
        (MP1-5) Impact of metastasectomy on metastatic renal cell carcinoma treatment---experience of taichung veterans general hospital
      6. 2.6
        (MP1-6) Bladder instillation with mitomycin or bacillus calmette-guérin in patients of non muscle invasive bladder cancer: eight years experiences
      7. 2.7
        (MP1-7) Outcome of second-look transurethral resection bladder tumor for superficial t1 bladder cancer - chi mei medical center experience
      8. 2.8
        (MP1-8) Allyl isothiocyanate up-regulates miR-30a-5p expression through a ROS responsive transcription factor, activator protein 1 (AP-1)
      9. 2.9
        (MP1-9) Chloroquine induces lysosomal disruptions and apoptotic cell death in bladder cancer cells
      10. 2.10
        (MP1-10) Analysis on post-operative delayed-ambulation patient after genitorurinary tract carcinoma- a medical center hospital based study in southern taiwan
      11. 2.11
        (MP2-1) Genuine overactive bladder is not common in children complaining isolated frequency
      12. 2.12
        (MP2-2) Alteration of cannabinoid receptor by phlorizin in type I diabetic rats’s bladder
      13. 2.13
        (MP2-3) Lower urinary tract symptoms and sexual function in low dose short-term ketamine abusers
      14. 2.14
        (MP2-4) The investigation of MAEL promoter methylation pattern in LINE1 expression by establishing targeted DNA methylation reporter system in human cell line
      15. 2.15
        (MP2-5) Application of a single camera stereoscopic endoscope in Urology surgery: A cases study on surgeon
      16. 2.16
        (MP2-6) Transurethral resection of the prostate could still achieve favorable in stroke patients with symptomatic benign prostate hyperplasia : implications from taiwan nationwide population-based cohort study
      17. 2.17
        (MP2-7) Lower urinary tract dysfunction with vesicoureteral reflux: a more significant factor predicting recurrent febrile uti in infants
      18. 2.18
        (MP2-8) Diabetes mellitus patients require higher rates of continuing medication after transurethral resection of prostate: implications from taiwan nationwide population-based cohort study
      19. 2.19
        (MP2-9) Human Polyomavirus Is Associated with Earlier Onset of Upper Urinary Tract Urothelial Carcinoma in Patients after Kidney transplantation
      20. 2.20
        (MP2-10) Is extracorporeal shock wave lithotripsy really safe in long-term follow up? A nationwide retrospective 6-year age matched non randomized study
      21. 2.21
        (MP3-1) Dual roles of benzyl isothiocycante-induced miR-99a in bladder cancer cells: Inducing autophagy and apoptosis
      22. 2.22
        (MP3-2) Safe abdominal entry in laparoscopic surgery
      23. 2.23
        (MP3-3) Does cognitive MRI-TRUS fusion targeted prostate biopsy have better gleason score concordance between biopsy and prostatectomy?
      24. 2.24
        (MP3-4) Subcutaneous drain for the prevention of wound infection after radical cystectomy with orthotopic neobladder reconstruction
      25. 2.25
        (MP3-5) Glycemic control improved the effect of instillation therapy in patient of non-muscle invasive bladder cancer
      26. 2.26
        (MP3-6) Partial cystectomy for bladder urothelial cancer: a 15-year experience in the single medical center experience
      27. 2.27
        (MP3-7) Long term outcome of Bladder cancer treatment in Show Chwan Memorial Hospital
      28. 2.28
        (MP3-8) Ureteroscopy-assisted laparoscopic segmental resection of ureteral stricture with a modified flank position: video demonstration and clinical experience
      29. 2.29
        (MP3-9) Hand-assisted laparoscopic adrenalectomy for large adrenal myelolipoma
      30. 2.30
        (MP3-10) Benign renal angiomyolipoma with renal vein and inferior vena cava thrombosis: a case report with review of literature
      31. 2.31
        (MP4-1) Investigation of trapped air pockets in the interface of coupling semiliquid and solid gasket in extracorporeal shock wave lithotripsy__ an experimental study
      32. 2.32
        (MP4-2) Minipercutaneous nephrolithotomy for renal stones: initial experience in Kaohsiung Veterans General HospitalMinipercutaneous nephrolithotomy for renal stones: initial experience in Kaohsiung Veterans General Hospital
      33. 2.33
        (MP4-3) Does PSA level affect the treatment outcomes in men with benign prostate hyperplasia using dutasteride?
      34. 2.34
        (MP4-4) The comparison of economical and clinical outcome in dealing with large proximal ureteral stone requiring multiple procedures between initial ureteroscopic lithotripsy or extracorporeal shock wave lithotripsy
      35. 2.35
        (MP4-5) Urologic complications during and after total hysterectomy and subsequent management --
      36. 2.36
        (MP4-6) Incidence and risk factor of bladder neck contracture after Bipolar versus Laser TUR-P An Experience From Show Chwan Memorial Hospital
      37. 2.37
        (MP4-7) How to achieve 200+ cases durability with flexbile ureteoscopes: a singel hospital experience
      38. 2.38
        (MP4-8) Distal ureteral reconstruction: six years’ experience in wan fang hospital
      39. 2.39
        (MP4-9) Drug adherence of alpha blocker for lower urinary tract symptoms related to benign prostatic hyperplasia-a single center experience
      40. 2.40
        (MP4-10) Exploration of perception gap of doctor-patient relationship at out-patient department from perspective of multiculturism: exemplified by a kaohsiung city teaching hopital
    3. 3.
      Non-Discussion Poster
      1. 3.1
        (NDP01) Acridine orange exhibits photodamages in human bladder cancer cells under blue light exposure
      2. 3.2
        (NDP02) Prostate cancer distribution in patients diagnosed by transrectal systemic random biopsy
      3. 3.3
        (NDP03) The diagnosis and treatment of testicular tumors: a 10-year experience at Changhua Christian Hospital
      4. 3.4
        (NDP04) Association between cyclooxygenase-2 expression and chemoresistance and invasiveness of human urothelial carcinoma in taiwanese
      5. 3.5
        (NDP05) Primary lymphoepithelioma-like carcinoma of the renal pelvis
      6. 3.6
        (NDP06) Primary urethral squamous cell carcinoma – A case report.
      7. 3.7
        (NDP07) Using Da Vinci Xi system to perform urological Surgery is more easily and feasible : E-Da Cancer Hospital initial experience
      8. 3.8
        (NDP08) A unusual cases report of urinary bladder tumor - cardinal tien hospital experience
      9. 3.9
        (NDP09) Renal mucinous tubular and spindle cell carcinoma – a case report
      10. 3.10
        (NDP10) Robot-assisted laparoscopic anatrophic nephrolithotomy in one 2 year-old child: a case report
      11. 3.11
        (NDP11) Rare urinary bladder tumor : paraganglioma – a case report
      12. 3.12
        (NDP12) Robotic-assisted laparoscopic calyceal diverticulectomy and partial oophorectomy: a case report
      13. 3.13
        (NDP13) Huge retroperitoneal teratoma with initial presentation of left hydronephrosis: a case report and review of literature
      14. 3.14
        (NDP14) Primary hyperaldosteronism manifested by rhabdomyolysis : a case report
      15. 3.15
        (NDP15) Using da Vinci Xi surgical system with intraoperative ultrasound to manage complex renal calyceal diverticular stones: a case report
      16. 3.16
        (NDP16) Ureteral small cell neuroendocrine carcinoma-case report
      17. 3.17
        (NDP17) Efficiency and safety of mirabegron in patients with urodynamic detrusor overactivity and inadequate detrusor contractility
      18. 3.18
        (NDP18) Efficacy and Safety of Parecoxib for reducing pyelovenous backflow pain during retrograde intrarenal surgery
      19. 3.19
        (NDP19) Viewing from evidence-based medicine on the 2016 tua pocket guidelines
      20. 3.20
        (NDP20) Renal Artery Stenting for traumatic total renal artery occlusion: A case report
      21. 3.21
        (NDP21) Primary mycotic aneurysm rupture with internal iliac artery pseudoaneurysm presenting as left septic pyonephrosis
      22. 3.22
        (NDP22)Successful repair of renal arterial rupture and arterial pseudoaneurysm in graft kidneys from the same deceased donor
      23. 3.23
        (NDP23) Staged surgery for the treatment of prostatic abscess
      24. 3.24
        (NDP24) Urethrocutaneous fistula and fournier’s gangrene developed after urethrolithotripsy-- a case report and review of literature
      25. 3.25
        (NDP25) Neoumbilicoplasty after excision of urachal cyst with abscess: a case report and review of literature
      26. 3.26
        (NDP26) A rare case of bladder hemangioma mimicking urachal tumor: a case and literature review
      27. 3.27
        (NDP27) Pelvic organ prolapse related giant urinary bladder stone – case report
      28. 3.28
        (NDP28) Case report: iatrogenic chyluira after lumbar spine debridement and reconstruction
      29. 3.29
        (NDP29) Case report: left inguinal cellular angiofibroma micmicking recurrence inguinal hernia
      30. 3.30
        (NDP30)　Subcutaneous emphysema after transurethral enucleation with bipolar: a case report with literature review
      31. 3.31
        (NDP31) Medical treatment of Retrograde ejaculation:A case report
      32. 3.32
        (NDP32) Sonography in the diagnosis of spontaneous perinephric urinoma during renal colic
      33. 3.33
        (NDP33) Optional treatmnets for a terminal-stage patient with emphysematous pyelonephritis - a case report
      34. 3.34
        (NDP34) A giant vesical claculus
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